Muscle to brain cross-talk in the molecular regulation of neuroplasticity and neurogenesis?

The overall purpose of the project is to investigate if the brain and the skeletal muscle releases proBDNF and mBDNF at rest and during exercise with different intensity, as well as try to identify which circulating pool (plasma or serum) that is most representative of exercise induced BDNF production. An additional purpose is to study how levels of released BDNF are related to peripheral levels and brain uptake of molecular candidates previously suggested to be involved in the molecular regulation of BDNF production.