William Apró
Projektforskare
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Akademisk titel
Medicine doktor i medicinsk vetenskap
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Tillhör
Institutionen för fysiologi, nutrition och biomekanik
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Kompetensprofil
Fysiologi, Träningslära
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Forskningsintressen
The overall aim of my research is to gain a deeper understanding of the molecular mechanisms that regulate protein synthesis and protein breakdown in human skeletal muscle. Specifically, I am investigating how amino acid and glycogen availability affects these processes in different populations, including both young and elderly men and women. A wide range of analytical techniques are used to study these mechanisms in both whole muscle and in specific fiber types.
Ultimately, the aim of my research is to provide new and translatable knowledge that can be used to promote healthy ageing as well as athletic performance.
Current projects
- Anabolic potential of skeletal muscle growth in healthy ageing.
- Fiber type specific regulation of protein synthesis in young and elderly muscle...
- Muscle protein breakdown and the role of glycogen availability and amino acid supplementation.
- Fiber type specific responses to energy and nutrient availability.
- Anabolic resistance in sarcopenia and obesity.
Representative publications
- Flockhart M, Nilsson LC, Tais S, Ekblom B, Apró W, Larsen FJ. Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers. Cell Metab. 2021 May 4;33(5):957-970.e6.
- Horwath O, Apró W, Moberg M, Godhe M, Helge T, Ekblom M, Hirschberg AL, Ekblom B. Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration in young women. J Appl Physiol (1985). 2020 May 1;128(5):1240-1250.
- Moberg M, Apró W, Ekblom B, van Hall G, Holmberg HC, Blomstrand E. Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C874-84.
- Apró W, Moberg M, Hamilton DL, Ekblom B, Rooyackers O, Holmberg HC, Blomstrand E. Leucine does not affect mechanistic target of rapamycin complex 1 assembly but is required for maximal ribosomal protein s6 kinase 1 activity in human skeletal muscle following resistance exercise. FASEB J. 2015 Oct;29(10):4358-73.
Current and potential financiers
Centrum för Idrottsforskning (CIF), Åke Wibergs Stiftelse, Sahlén Stiftelsen, Lars Hiertas Minnesfond, Europeiska forskningsrådet (ERC).
Senaste publikationer (DiVA)
Sida 1 av 9
(Totalt antal hämtade artiklar: 41)
Apró, William
Moberg, Marcus
Ekblom, Björn
Rooyackers, O
Holmberg, HC
Blomstrand, Eva
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Leucine does not affect mTORC1 assembly but is required for maximal S6K1 activity in human skeletal muscle following resistance exercise |
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Tannerstedt, Jörgen
Apró, William
Blomstrand, Eva
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Maximal lengthening contractions induce different signaling responses in the type I and type II fibers of human skeletal muscle. |
2009 |
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Apró, William
Blomstrand, Eva
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Influence of supplementation with branched-chain amino acids in combination with resistance exercise on p70S6 kinase phosphorylation in resting and exercising human skeletal muscle. |
2010 |
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Apró, William
Holmberg, Hans-Christer
Rooyackers, Olav
Blomstrand, Eva
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Is leucine induced p70S6 kinase phosphorylation following resistance exercise dependent on elevated phenylalanine levels in human skeletal muscle? |
2010 |
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Mascher, Henrik
Apró, William
Pontén, Marjan
Ekblom, Björn
Blomstrand, Eva
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Effects of essential amino acid supplementation on markers for anabolic and catabolic response to resistance exercise in female subjects |
2010 |
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Övrigt
Postdoc under 2 år vid University of Birmingham, England.
Medlem i Riksidrottsförbundets nätverk för idrottsnutritionsrådgivare.
Högupplösta bilder
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