Oscar Horwath

Akademisk titel

Magisterexamen i biomedicin, Masterexamen i fysiologi och medicin

Tillhör

Institutionen för fysiologi, nutrition och biomekanik

Kompetensprofil

Fysiologi, Träningslära

Forskningsintressen

My research interests largely revolve around cellular and molecular mechanisms that control skeletal muscle mass and how these are influenced by factors such as age, hormonal status, oxygen- and energy availability, exercise, and nutrition.

In my PhD-project, using both in vitro and in vivo approaches, I have focused on the underlying causes of anabolic resistance, i.e., impaired sensitivity to exercise and nutrition, within the context of sarcopenia and obesity. My work improves the molecular understanding of how ageing and obesity impact skeletal muscle adaptability, which may facilitate the development of new treatments to combat muscle wasting in elderly populations.  

Current projects

1. The role of obesity in age-related anabolic resistance.
2. The effect of testosterone administration on skeletal muscle in young women.
3. The role of glycogen availability in autophagy signaling and adaptation to resistance exercise.
4. The role of oxygen levels on the early satellite cell response to resistance exercise.
   
   

Representative publications 

• Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration in young women. Horwath O, Apró W, Moberg M, Godhe M, Helge T, Ekblom M, Hirschberg AL, Ekblom B. J Appl Physiol (1985). 2020 May 1;128(5):1240-1250. doi: 10.1152/japplphysiol.00893.2019. Epub 2020 Mar 19.
• Enhanced Skeletal Muscle Oxidative Capacity and Capillary-to-Fiber Ratio Following Moderately Increased Testosterone Exposure in Young Healthy Women. Cardinale DA, Horwath O, Elings-Knutsson J, Helge T, Godhe M, Bermon S, Moberg M, Flockhart M, Larsen FJ, Hirschberg AL, Ekblom B. Front Physiol. 2020 Dec 3;11:585490. doi: 10.3389/fphys.2020.585490. eCollection 2020.
  
• Influence of sex and fiber type on the satellite cell pool in human skeletal muscle. Horwath O, Moberg M, Larsen FJ, Philp A, Apró W, Ekblom B. Scand J Med Sci Sports. 2021 Feb;31(2):303-312. doi: 10.1111/sms.13848. Epub 2020 Oct 20.